68. Primary Hyperparathyroidism

  1. Clifford J. Rosen MD
  1. Shonni J. Silverberg

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch68

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Silverberg, S. J. (2013) Primary Hyperparathyroidism, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch68

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • hypercalcemia;
  • parathyroid hormone (PTH);
  • primary hyperparathyroidism

Summary

Primary hyperparathyroidism is a disorder resulting from excessive secretion of parathyroid hormone (PTH) from one or more of the four parathyroid glands. This chapter deals exclusively with the clinical presentation, evaluation, diagnosis, and therapy of primary hyperparathyroidism. Pathological examination of the malignant tissue might show mitoses, vascular or capsular invasion, and fibrous trabeculae. The pathophysiology of primary hyperparathyroidism relates to the loss of normal feedback control of PTH by extracellular calcium. Under virtually all other hypercalcemic conditions, there is feedback suppression of the parathyroid glands, and PTH levels are very low or undetectable. The molecular basis for primary hyperparathyroidism remains elusive in the vast majority of patients. The diagnosis of primary hyperparathyroidism is established by laboratory tests. The biochemical hallmarks of primary hyperparathyroidism are hypercalcemia (except in patients with normocalcemic primary hyperparathyroidism) and elevated levels of PTH.