72. Hypoparathyroidism and Pseudohypoparathyroidism

  1. Clifford J. Rosen MD
  1. Mishaela R. Rubin and
  2. Michael A. Levine

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch72

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Rubin, M. R. and Levine, M. A. (2013) Hypoparathyroidism and Pseudohypoparathyroidism, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch72

Publication History

  1. Published Online: 19 JUL 2013
  2. Published Print: 19 AUG 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • functional hypoparathyroidism;
  • pseudohypoparathyroidism

Summary

This chapter discusses the clinical manifestations, differential diagnosis, diagnostic algorithm, and treatment of functional hypoparathyroidism and pseudohypoparathyroidism. The term “functional hypoparathyroidism” refers to a group of metabolic disorders in which hypocalcemia and hyperphosphatemia occur either from a failure of the parathyroid glands to secrete adequate amounts of biologically active parathyroid hormone (PTH) or, less commonly, from an inability of PTH to elicit appropriate biological responses in its target tissues. Plasma concentrations of PTH are low or absent in patients with true hypoparathyroidism (HP). By contrast, plasma concentrations of PTH are elevated in patients with pseudohypoparathyroidism (PHP), and reflect the failure of target tissues to respond appropriately to the biological actions of PTH. The signs and symptoms of functional hypoparathyroidism are principally manifestations of a reduced concentration of ionized extracellular calcium. The goal of therapy in hypoparathyroidism is to restore serum calcium as close to normal as possible.