75. Vitamin D-Related Disorders

  1. Clifford J. Rosen MD
  1. Paul Lips,
  2. Natasja M. van Schoor and
  3. Nathalie Bravenboer

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch75

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Lips, P., van Schoor, N. M. and Bravenboer, N. (2013) Vitamin D-Related Disorders, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch75

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • nutritional rickets;
  • osteomalacia;
  • vitamin D intoxication;
  • vitamin D-related disorders

Summary

This chapter discusses the more classical vitamin D-related disorders such as nutritional rickets and osteomalacia, genetic disorders of vitamin D synthesis and function. Vitamin D intoxication is also considered. The spectrum of rickets and osteomalacia includes vitamin D—related and other causes such as liver disease, malabsorption, drugs and renal diseases. A transiliac bone biopsy after tetracycline double labeling provides a certain diagnosis of osteomalacia or can exclude it. The symptoms of rickets and osteomalacia may disappear with remarkably low doses of vitamin D3 unless intestinal absorption is impaired as in celiac disease. The observation that some forms of rickets could not be cured by regular doses of vitamin D led to the discovery of rare inherited abnormalities of vitamin D metabolism or the vitamin D receptor. Vitamin D intoxication is caused by increased ingestion of vitamin D or one of its active metabolites, e.g., alphacalcidol or calcitriol.