82. Clinical and Preclinical Imaging in Osseous Metastatic Disease

  1. Clifford J. Rosen MD
  1. Geertje van der Horst and
  2. Gabri van der Pluijm

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch82

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

van der Horst, G. and van der Pluijm, G. (2013) Clinical and Preclinical Imaging in Osseous Metastatic Disease, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch82

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • anatomical imaging techniques;
  • functional imaging;
  • image-guided surgery;
  • molecular imaging techniques;
  • morphological imaging techniques;
  • multimodality imaging;
  • osseous metastatic disease

Summary

Bone metastases are frequent complications of cancer, occurring in up to 80% of patients with advanced breast or prostate cancer and in approximately 15-30% of patients with carcinoma of the thyroid, lung, bladder, or kidney. In addition, melanomas and multiple myeloma also readily metastasize to the skeleton. Imaging has become an indispensible tool in the diagnosis and treatment of skeletal metastasis both in the clinic and experimentally. Novel multimodality imaging approaches are emerging rapidly and greatly facilitate experimental studies in preclinical models of metastatic bone disease. This chapter talks about some of the approaches such as morphological/anatomical imaging techniques, molecular/functional imaging techniques, image-guided surgery, multimodality imaging, and functional imaging. Multimodality imaging promises to make significant contribution to both the staging and management of osseous metastatic disease.