83. Metastatic Solid Tumors to Bone

  1. Clifford J. Rosen MD
  1. Rachelle W. Johnson and
  2. Julie A. Sterling

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch83

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Johnson, R. W. and Sterling, J. A. (2013) Metastatic Solid Tumors to Bone, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch83

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • animal models;
  • bone;
  • bone metastases;
  • metastatic solid tumors;
  • molecular mechanisms;
  • osteoblastic metastases;
  • osteolytic factors

Summary

Cancer metastasis to bone is a common problem in patients with metastatic tumors, such as breast, prostate, and lung cancers. Bone metastases are incurable, and while treatments have improved, the patients will eventually die from the disease. Some of the most common models of tumor-induced bone disease include tail vein, cardiac, and intratibial inoculation of breast tumor cells. This chapter deals with molecular mechanisms of bone metastasis (osteolytic and osteoblastic factors), and tumor microenvironment regulation of bone disease. Despite decades of research focusing on the treatment of bone metastases, they remain incurable. Bisphosphonates are currently the clinical standard of care for treating patients with bone metastases and have been highly effective in patients to reduce fractures and improve quality of life.