89. Skeletal Complications of Childhood Cancer

  1. Clifford J. Rosen MD
  1. Ingrid A. Holm

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch89

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Holm, I. A. (2013) Skeletal Complications of Childhood Cancer, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch89

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • acute lymphocytic leukemia (ALL);
  • bone mineral density (BMD);
  • chemotherapy;
  • childhood cancer;
  • skeletal complications

Summary

With improvements in therapy, more and more children are surviving childhood cancer. As more and more children with cancer are surviving, the number of adults with complications from cancer is increasing. This chapter focuses on one of the long-term sequelae: deficits in bone mineral density (BMD). Acute lymphocytic leukemia (ALL) is the most common childhood malignancy and much literature on the skeletal effects of cancer focuses on this population. An important long-term consequence of childhood cancer is deficits in bone mass accrual that often persist into adulthood, thereby increasing the risk of osteoporosis and fractures. The chemotherapies and radiation therapies used to treat these cancers are in large part responsible for the increased risk of a low BMD. The hope is that the early detection of bone mineral deficits and treatment of the modifiable factors will improve the prognosis in survivors of childhood cancer.