9. Animal Models: Allelic Determinants for BMD

  1. Clifford J. Rosen MD
  1. Robert D. Blank

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch9

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

D. Blank, R. (2013) Animal Models: Allelic Determinants for BMD, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch9

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • allelic determinants;
  • bone mineral density (BMD);
  • mice;
  • phenotypes

Summary

This chapter presents examples to illustrate the impact of allelic variation on skeletal phenotypes in mice. It encompasses two broad areas. First, the chapter explains the phenotypes studied in mice. Next, it summarizes the general themes emerging from the data. The contemporary era of mouse bone genetics began with the demonstration that inbred mouse strains differ in apparent volumetric bone mineral density (BMD), using peripheral quantitative computed tomography (pQCT) scanning. Finally, the chapter explores expected directions for future work. The genetic tools available in the mouse allow resourceful investigators to continue to learn new biology that can be applied to improving the human condition.