14. Gamma-Hydroxybutyrate for Treatment of Alcohol Withdrawal and Prevention of Relapse

  1. Iosief Abraha1 and
  2. Cristina Cusi2

Published Online: 13 AUG 2012

DOI: 10.1002/9781118454503.ch14

Alcohol and Drug Misuse

Alcohol and Drug Misuse

How to Cite

Abraha, I. and Cusi, C. (2012) Gamma-Hydroxybutyrate for Treatment of Alcohol Withdrawal and Prevention of Relapse, in Alcohol and Drug Misuse, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118454503.ch14

Author Information

  1. 1

    Regional Health Authority of Umbria, Perugia, Italy

  2. 2

    Outpatient Services – Neurology, Clinical Institutes of Specialisation, Milan, Italy

Publication History

  1. Published Online: 13 AUG 2012
  2. Published Print: 7 AUG 2012

ISBN Information

Print ISBN: 9780470659694

Online ISBN: 9781118454503



  • GHB for treatment of alcohol withdrawal, and relapse prevention;
  • GHB, short-chain fatty acid, metabolite of gamma-amino-butyric acid;
  • GHB, and dopamine/serotonin/acetylcholine/opioid modulation;
  • GHB's alcohol-mimicking effects, in alcohol dependence and craving;
  • efficacy and safety of GHB for alcohol withdrawal and relapse;
  • primary outcomes, drop-out/abstinence rate, secondary in length of stay;
  • alcohol-dependent in accordance with appropriate standardised criteria;
  • alcohol craving scale, results favouring GHB over placebo;
  • GHB better in maintaining abstinence/craving in medium term;
  • GHB in alcohol withdrawal, evaluation in unintended detoxifications


This chapter contains sections titled:

  • Reference