37. Alpha2-Adrenergic Agonists for the Management of Opioid Withdrawal1

  1. Iosief Abraha1 and
  2. Cristina Cusi2

Published Online: 13 AUG 2012

DOI: 10.1002/9781118454503.ch37

Alcohol and Drug Misuse

Alcohol and Drug Misuse

How to Cite

Abraha, I. and Cusi, C. (2012) Alpha2-Adrenergic Agonists for the Management of Opioid Withdrawal1, in Alcohol and Drug Misuse, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118454503.ch37

Author Information

  1. 1

    Regional Health Authority of Umbria, Perugia, Italy

  2. 2

    Outpatient Services – Neurology, Clinical Institutes of Specialisation, Milan, Italy

Publication History

  1. Published Online: 13 AUG 2012
  2. Published Print: 7 AUG 2012

ISBN Information

Print ISBN: 9780470659694

Online ISBN: 9781118454503



  • alpha2-adrenergic agonists, for management of opioid withdrawal;
  • alpha2-adrenergic, and effectiveness in opioid withdrawal;
  • relapse to opioid following detoxification, high/withdrawal low;
  • alpha2-adrenergic, moderating symptoms of noradrenergic hyperactivity;
  • clonidine/lofexidine effectiveness for withdrawal from heroin/methadone;
  • other outcomes, signs/symptoms and overall withdrawal experienced;
  • population, primarily opioid-dependent under managed withdrawal;
  • clonidine and adverse effects, than reducing doses of methadone


This chapter contains sections titled:

  • Reference