41. Methadone Maintenance at Different Dosages for Opioid Dependence1

  1. Iosief Abraha1 and
  2. Cristina Cusi2

Published Online: 13 AUG 2012

DOI: 10.1002/9781118454503.ch41

Alcohol and Drug Misuse

Alcohol and Drug Misuse

How to Cite

Abraha, I. and Cusi, C. (2012) Methadone Maintenance at Different Dosages for Opioid Dependence1, in Alcohol and Drug Misuse, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118454503.ch41

Author Information

  1. 1

    Regional Health Authority of Umbria, Perugia, Italy

  2. 2

    Outpatient Services – Neurology, Clinical Institutes of Specialisation, Milan, Italy

Publication History

  1. Published Online: 13 AUG 2012
  2. Published Print: 7 AUG 2012

ISBN Information

Print ISBN: 9780470659694

Online ISBN: 9781118454503



  • methadone maintenance at different dosages for opioid dependence;
  • appropriate dose of methadone in retaining patients in opioid-dependent;
  • methadone maintenance, a long-term opioid replacement therapy;
  • evaluating efficacy/safety of dosage of methadone for opioid dependence;
  • methadone, 60 to 100 mg/day more effective than low doses;
  • heterogeneity and outcome reporting bias, threats to validity of results;
  • effect of methadone dose in mortality reduction


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  • Reference