43. Opioid Antagonists Under Heavy Sedation or Anaesthesia for Opioid Withdrawal1

  1. Iosief Abraha1 and
  2. Cristina Cusi2

Published Online: 13 AUG 2012

DOI: 10.1002/9781118454503.ch43

Alcohol and Drug Misuse

Alcohol and Drug Misuse

How to Cite

Abraha, I. and Cusi, C. (2012) Opioid Antagonists Under Heavy Sedation or Anaesthesia for Opioid Withdrawal1, in Alcohol and Drug Misuse, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118454503.ch43

Author Information

  1. 1

    Regional Health Authority of Umbria, Perugia, Italy

  2. 2

    Outpatient Services – Neurology, Clinical Institutes of Specialisation, Milan, Italy

Publication History

  1. Published Online: 13 AUG 2012
  2. Published Print: 7 AUG 2012

ISBN Information

Print ISBN: 9780470659694

Online ISBN: 9781118454503



  • opioid antagonists under sedation/anaesthesia for opioid withdrawal;
  • opioid antagonists in inducing withdrawal with sedation/anaesthesia;
  • opioid antagonist effectiveness and opioid withdrawal;
  • participants, opioid dependent under managed withdrawal;
  • antagonist-induced withdrawal, intense/less prolonged than of methadone;
  • sedation levels, no effect on withdrawal, duration playing a role;
  • risk of adverse events, with heavy sedation;
  • opioid antagonist use, being promoted despite its life-threatening risks;
  • antagonist-induced withdrawal under sedation, unsupported;
  • strategy towards minimal sedation approaches


This chapter contains sections titled:

  • Reference