44. Opioid Antagonists with Minimal Sedation for Opioid Withdrawal1

  1. Iosief Abraha1 and
  2. Cristina Cusi2

Published Online: 13 AUG 2012

DOI: 10.1002/9781118454503.ch44

Alcohol and Drug Misuse

Alcohol and Drug Misuse

How to Cite

Abraha, I. and Cusi, C. (2012) Opioid Antagonists with Minimal Sedation for Opioid Withdrawal1, in Alcohol and Drug Misuse, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118454503.ch44

Author Information

  1. 1

    Regional Health Authority of Umbria, Perugia, Italy

  2. 2

    Outpatient Services – Neurology, Clinical Institutes of Specialisation, Milan, Italy

Publication History

  1. Published Online: 13 AUG 2012
  2. Published Print: 7 AUG 2012

ISBN Information

Print ISBN: 9780470659694

Online ISBN: 9781118454503



  • opioid antagonists with minimal sedation in opioid withdrawal;
  • opioid antagonists, dependence to abstinence in withdrawal;
  • opioid effectiveness in combination with minimal sedation;
  • primary outcomes, withdrawal intensity and treatment duration;
  • other outcomes, participant number increase in further treatments;
  • withdrawal intensity, by opioid antagonists and adrenergic agonist;
  • delirium, following first doses of opioid antagonist;
  • antagonist-induced withdrawal, and higher rates of completion;
  • opioid antagonists with alpha2-adrenergic, feasible;
  • evidence on opioid effectiveness, low and uncertain


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