15. Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy
- John W. Miller MD, PhD Director, UW Regional Epilepsy Center, Professor of Neurology and Neurological Surgery2 and
- Howard P. Goodkin MD, PhD The Shure Professor of Neurology and Pediatrics, Director, Division of Pediatric Neurology3
Published Online: 10 JAN 2014
Copyright © 2014 John Wiley & Sons, Ltd.
How to Cite
Poolos, N. P. (2014) Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy, in Epilepsy (eds J. W. Miller and H. P. Goodkin), John Wiley & Sons, Oxford. doi: 10.1002/9781118456989.ch15
University of Washington, Seattle, WA, USA
Department of Neurology, University of Virginia, Charlottesville, VA, USA
- Published Online: 10 JAN 2014
- Published Print: 14 FEB 2014
Print ISBN: 9781118456941
Online ISBN: 9781118456989
- seizure exacerbation;
- AED mechanism of action
Refractory epilepsy affects about one-third of all epilepsy patients, yet there are few evidence-based guidelines for its treatment. The likelihood of treatment success is increased by definitively establishing the epilepsy diagnosis through video–EEG monitoring, emphasizing compliance with treatment and avoiding provocation by alcohol abuse, and avoiding antiepileptic drugs (AED) that exacerbate seizures in generalized epilepsy. Persistence in trying different AED combinations sometimes arrives at a successful drug regimen, thus neither the clinician nor the patient should give up hope in this difficult to treat condition.