20. Seizures in the Neonate

  1. John W. Miller MD, PhD Director, UW Regional Epilepsy Center, Professor of Neurology and Neurological Surgery3 and
  2. Howard P. Goodkin MD, PhD The Shure Professor of Neurology and Pediatrics, Director, Division of Pediatric Neurology4
  1. Adam L. Hartman1 and
  2. Frances J. Northington2

Published Online: 10 JAN 2014

DOI: 10.1002/9781118456989.ch20



How to Cite

Hartman, A. L. and Northington, F. J. (2014) Seizures in the Neonate, in Epilepsy (eds J. W. Miller and H. P. Goodkin), John Wiley & Sons, Oxford. doi: 10.1002/9781118456989.ch20

Editor Information

  1. 3

    University of Washington, Seattle, WA, USA

  2. 4

    Department of Neurology, University of Virginia, Charlottesville, VA, USA

Author Information

  1. 1

    Divisions of Epilepsy and Pediatric Neurology, Neurosciences Intensive Care Nursery, Johns Hopkins Medicine Baltimore, MD, USA

  2. 2

    Division of Neonatology, Neurosciences Intensive Care Nursery, Neonatal Research Laboratory, Johns Hopkins Medicine, Baltimore, MD, USA

Publication History

  1. Published Online: 10 JAN 2014
  2. Published Print: 14 FEB 2014

ISBN Information

Print ISBN: 9781118456941

Online ISBN: 9781118456989



  • neonate;
  • seizures;
  • EEG;
  • amplitude integrated EEG ;
  • continuous video EEG ;
  • neuroimaging


The initial presentation of seizures in a neonate should in general be considered an urgent condition, requiring close monitoring and a thorough diagnostic evaluation to exclude treatable and life-threatening conditions. electroencephalogram (EEG) monitoring (including continuous video–EEG and amplitude integrated EEG) remains the foundation of an accurate diagnosis of seizures but rapidly evolving neuroimaging techniques and genetic markers are expanding our ability to identify an underlying etiology. This chapter provides an overview of diagnosis and treatment of neonatal seizures. We also present a protocol for initial diagnosis and therapy for neonatal seizures used in our Neurosciences Intensive Care Nursery program.