44. Rare B Cell Lymphoproliferative Disorders

  1. Derek Raghavan MD, PhD, FACP, FRACP, FASCO President, Professor/Medicine2,
  2. Charles D. Blanke MD, FACP, FRCPC, FASCO Vice-President, Professor and Chief3,
  3. David H. Johnson MD4,
  4. Paul L. Moots MD Associate Professor of Neurology and Medicine, Chief5,
  5. Gregory H. Reaman MD Professor of Pediatrics and Medicine6,
  6. Peter G. Rose MD Head7 and
  7. Mikkael A. Sekeres MD, MS Director8
  1. Paul M. Barr and
  2. Jonathan W. Friedberg

Published Online: 20 SEP 2012

DOI: 10.1002/9781118464557.ch44

Textbook of Uncommon Cancer

Textbook of Uncommon Cancer

How to Cite

Barr, P. M. and Friedberg, J. W. (2012) Rare B Cell Lymphoproliferative Disorders, in Textbook of Uncommon Cancer (eds D. Raghavan, C. D. Blanke, D. H. Johnson, P. L. Moots, G. H. Reaman, P. G. Rose and M. A. Sekeres), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118464557.ch44

Editor Information

  1. 2

    Levine Cancer Institute, Carolinas HealthCare System; University of North Carolina School of Medicine, Charlotte, NC, USA

  2. 3

    Systemic Therapy, British Columbia Cancer Agency; Medical Oncology, University of British Columbia, Vancouver, BC, Canada

  3. 4

    Donald W. Seldin Distinguished Chair in Internal Medicine, Professor and Chairman, Department of Internal Medicine, The University of Texas Southwestern School of Medicine, Dallas, TX, USA

  4. 5

    Division of Neuro-Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center; Tennessee Valley Healthcare Systems, Veterans Administration Medical Center, Nashville, TN, USA

  5. 6

    The George Washington University School of Medicine and Health Sciences, Children's National Medical Center, Washington, DC, USA

  6. 7

    Section of Gynecologic Oncology, Cleveland Clinic Taussig Cancer Center; Professor of Medicine, Case Western Reserve University, Cleveland, OH, USA

  7. 8

    Leukemia Program, Associate Professor of Medicine, Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA

Author Information

  1. Department of Medicine, James P. Wilmot Cancer Center, University of Rochester, Rochester, NY, USA

Publication History

  1. Published Online: 20 SEP 2012
  2. Published Print: 22 FEB 2012

ISBN Information

Print ISBN: 9781118083734

Online ISBN: 9781118464557



  • B cell lymphoma;
  • B cell prolymphocytic leukemia;
  • BL;
  • Castleman disease;
  • classic Hodgkin lymphoma;
  • Hairy cell leukemia;
  • Intravascular large B cell lymphoma;
  • LG;
  • NLPHL;
  • PEL;
  • Rare B cell lymphoproliferative disorders


This chapter focuses on the rarest of the mature B cell neoplasms as defined in the current World Health Organization classification, the current reference for classification of hematological malignancies. As with any classification system, it is constantly evolving based on available technology and data, and periodically updated reflecting this rapidly evolving field. As such, this chapter provides a “snapshot” of these uncommon diagnoses. The summarized data can assist in guiding the diagnosis and management in certain cases, while in others the data only highlight our lack of knowledge. To better inform the practicing oncologist, we focus on entities for which large prospective studies are not available. As they are covered elsewhere, we will not include plasma cell neoplasms or cutaneous diseases.