19. Fertility Issues, Contraception, and Pregnancy Outcome in Long-Term Survivors

  1. Bipin N Savani MD
  1. Alicia Rovó1,
  2. Nina Salooja2,
  3. Carl P Schwarze3,
  4. Joerg P Halter1 and
  5. André Tichelli1

Published Online: 6 SEP 2013

DOI: 10.1002/9781118473306.ch19

Blood and Marrow Transplantation Long-Term Management: Prevention and Complications

Blood and Marrow Transplantation Long-Term Management: Prevention and Complications

How to Cite

Rovó, A., Salooja, N., Schwarze, C. P., Halter, J. P. and Tichelli, A. (2013) Fertility Issues, Contraception, and Pregnancy Outcome in Long-Term Survivors, in Blood and Marrow Transplantation Long-Term Management: Prevention and Complications (ed B. N. Savani), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118473306.ch19

Editor Information

  1. Professor of Medicine,Director, Long Term Transplant Clinic, Hematology and Stem Cell Transplantation Section, Vanderbilt University Medical Center, Nashville, TN, USA

Author Information

  1. 1

    Hematology Department, University Hospital of Basel, Basel, Switzerland

  2. 2

    Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK

  3. 3

    University Children's Hospital, Tübingen, Germany

Publication History

  1. Published Online: 6 SEP 2013
  2. Published Print: 1 OCT 2013

ISBN Information

Print ISBN: 9781118473405

Online ISBN: 9781118473306

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Keywords:

  • hematopoietic stem cell transplantation;
  • fertility;
  • gonadal failure;
  • pregnancy

Summary

As the long-term survival rate of patients receiving hematopoietic stem cell transplantation (HSCT) increases, quality-of-life issues, including the possibility to parent children, gain more attention. Infertility is common following HSCT usually as a result of the chemoradiotherapy given for pretransplant conditioning. The underlying disease and its treatment prior to transplant can also play a role. Fertility and paternity issues are frequent problems that a long-term survivor and their respective partner face, and it represents a challenge for the transplantation team to overcome infertility and its consequences. The best option to prevent infertility as a late effect after HSCT is indeed to raise awareness in the medical community about fertility preservation. This chapter focuses on fertility issues, contraception, and pregnancy outcome in long-term survivors.