22. Thyroid Disease: Monitoring and Management Guidelines

  1. Bipin N Savani MD
  1. M Kathleen Figaro1,
  2. Cheryl A Fassler2,
  3. Shubhada Jagasia1 and
  4. Vipul T Lakhani1

Published Online: 6 SEP 2013

DOI: 10.1002/9781118473306.ch22

Blood and Marrow Transplantation Long-Term Management: Prevention and Complications

Blood and Marrow Transplantation Long-Term Management: Prevention and Complications

How to Cite

Figaro, M. K., Fassler, C. A., Jagasia, S. and Lakhani, V. T. (2013) Thyroid Disease: Monitoring and Management Guidelines, in Blood and Marrow Transplantation Long-Term Management: Prevention and Complications (ed B. N. Savani), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118473306.ch22

Editor Information

  1. Professor of Medicine,Director, Long Term Transplant Clinic, Hematology and Stem Cell Transplantation Section, Vanderbilt University Medical Center, Nashville, TN, USA

Author Information

  1. 1

    Division of Diabetes, Endocrinology & Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA

  2. 2

    University of Tennessee Health Science Center/Baptist Hospital, Nashville, TN, USA

Publication History

  1. Published Online: 6 SEP 2013
  2. Published Print: 1 OCT 2013

ISBN Information

Print ISBN: 9781118473405

Online ISBN: 9781118473306

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Keywords:

  • thyroid function abnormalities;
  • post allo-HCT;
  • hypothyroidism;
  • hyperthyroidism;
  • thyroid nodule;
  • thyroid cancer;
  • thyroid and pregnancy;
  • tyrosine kinase inhibitor;
  • thyrotropin

Summary

Hematopoietic allogeneic stem-cell transplantation (allo-HCT) has become a common treatment option for a variety of hematologic diseases. Steady increases in survival following transplantation have led to an increased focus on long-term complications. Posttransplant thyroid disease commonly occurs both acutely and chronically in allo-HCT recipients. Most frequently, hypothyroidism ensues; however, hyperthyroidism and thyroid nodules are also documented. In this chapter we review the functional and anatomical thyroid abnormalities associated with allo-HCT. We summarize risk factors, signs, and symptoms, and recommend diagnostic, treatment, and follow-up strategies to normalize thyroid function during and post transplant. By addressing the thyroid complications of allo-HCT, clinicians can minimize the risk of debilitating complications associated with untreated thyroid disease and improve the quality of life in transplant recipients.