28. Hepatic Complications of Hematopoietic Stem Cell Transplantation

  1. Bipin N Savani MD
  1. Niharika Samala1,
  2. Preet Bagi2,
  3. Theo Heller1 and
  4. Steven Pavletic3

Published Online: 6 SEP 2013

DOI: 10.1002/9781118473306.ch28

Blood and Marrow Transplantation Long-Term Management: Prevention and Complications

Blood and Marrow Transplantation Long-Term Management: Prevention and Complications

How to Cite

Samala, N., Bagi, P., Heller, T. and Pavletic, S. (2013) Hepatic Complications of Hematopoietic Stem Cell Transplantation, in Blood and Marrow Transplantation Long-Term Management: Prevention and Complications (ed B. N. Savani), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118473306.ch28

Editor Information

  1. Professor of Medicine,Director, Long Term Transplant Clinic, Hematology and Stem Cell Transplantation Section, Vanderbilt University Medical Center, Nashville, TN, USA

Author Information

  1. 1

    Liver Disease Branch, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA

  2. 2

    The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA

  3. 3

    Graft-versus-Host and Autoimmunity Unit, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

Publication History

  1. Published Online: 6 SEP 2013
  2. Published Print: 1 OCT 2013

ISBN Information

Print ISBN: 9781118473405

Online ISBN: 9781118473306

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Keywords:

  • liver;
  • hepatic;
  • complications;
  • transplantation;
  • survivorship;
  • late effects

Summary

Hematopoietic stem cell transplantion (HSCT) poses a unique therapeutic challenge: balancing the benefit of the graft-versus-tumor effect against the risk of graft-versus-host complications. Liver abnormalities in this population can be a diagnostic challenge as their differential is broad. Furthermore, liver chemistries often fluctuate and clinical symptoms can be subtle to absent. Possible hepatic complications in this cohort include: graft-versus-host disease, iron overload, sinusoidal obstruction syndrome, viral hepatitis, and drug-induced liver injury. Furthermore, HSCT patients are at risk of the same liver diseases that can affect the general population, and these must be not be neglected.