15. Modeling of Ventricular Arrhythmias

  1. Mohammad Shenasa MD2,
  2. Gerhard Hindricks MD3,
  3. Martin Borggrefe MD4,
  4. Günter Breithardt MD5 and
  5. Mark E. Josephson MD6
  1. Natalia A. Trayanova

Published Online: 18 DEC 2012

DOI: 10.1002/9781118481585.ch15

Cardiac Mapping, Fourth Edition

Cardiac Mapping, Fourth Edition

How to Cite

Trayanova, N. A. (2013) Modeling of Ventricular Arrhythmias, in Cardiac Mapping, Fourth Edition (eds M. Shenasa, G. Hindricks, M. Borggrefe, G. Breithardt and M. E. Josephson), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118481585.ch15

Editor Information

  1. 2

    Attending Physician, Department of Cardiovascular Services, O'Connor Hospital, Heart & Rhythm Medical Group, San Jose, California, USA

  2. 3

    Professor of Medicine (Cardiology), University Leipzig, Heart Center, Director, Department of Electrophysiology, Leipzig, Germany

  3. 4

    Professor of Medicine (Cardiology), Head, Department of Cardiology, Angiology and Pneumology, University Medical Center, Mannheim Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  4. 5

    Professor Emeritus of Medicine and Cardiology, Department of Cardiology and Angiology, Hospital of the University of Münster, Münster, Germany

  5. 6

    Chief, Cardiovascular Medicine Division, Director, Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service, Beth Israel Deaconess Medical Center, Herman C. Dana Professor of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. Department of Biomedical Engineering and Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD, USA

Publication History

  1. Published Online: 18 DEC 2012
  2. Published Print: 10 JAN 2013

ISBN Information

Print ISBN: 9780470670460

Online ISBN: 9781118481585

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Keywords:

  • ventricular model;
  • cardiac arrhythmias;
  • reentry;
  • simulation;
  • multi-scale modeling;
  • image-based models;
  • drug-induced arrhythmias;
  • fibroblasts;
  • ischemia;
  • infarction

Summary

The heart is the organ for which modeling and simulation have achieved the highest degree of sophistication. Among the applications of multi-scale heart models, modeling ventricular arrhythmias has been on the forefront of cardiac simulation research, driven by the significance of uncovering the mechanisms underlying sudden cardiac death. The goal of this review article is to assess the current state of ventricular arrhythmia modeling. We first present the general approach to modeling cardiac arrhythmias at the organ level. We then review specific applications of three-dimensional ventricular multi-scale modeling in elucidating the mechanisms of reentrant arrhythmias in the ventricles. The article showcases the contributions that ventricular modeling and simulation have made to our understanding of the cardiac rhythm disorders. A summary of the future developments envisioned for the field of ventricular arrhythmia modeling is also presented.