33. Is There a Role For Mapping of Dominant Frequency in Human Atrial Fibrillation?

  1. Mohammad Shenasa MD2,
  2. Gerhard Hindricks MD3,
  3. Martin Borggrefe MD4,
  4. Günter Breithardt MD5 and
  5. Mark E. Josephson MD6
  1. Hakan Oral and
  2. Fred Morady

Published Online: 18 DEC 2012

DOI: 10.1002/9781118481585.ch33

Cardiac Mapping, Fourth Edition

Cardiac Mapping, Fourth Edition

How to Cite

Oral, H. and Morady, F. (2013) Is There a Role For Mapping of Dominant Frequency in Human Atrial Fibrillation?, in Cardiac Mapping, Fourth Edition (eds M. Shenasa, G. Hindricks, M. Borggrefe, G. Breithardt and M. E. Josephson), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118481585.ch33

Editor Information

  1. 2

    Attending Physician, Department of Cardiovascular Services, O'Connor Hospital, Heart & Rhythm Medical Group, San Jose, California, USA

  2. 3

    Professor of Medicine (Cardiology), University Leipzig, Heart Center, Director, Department of Electrophysiology, Leipzig, Germany

  3. 4

    Professor of Medicine (Cardiology), Head, Department of Cardiology, Angiology and Pneumology, University Medical Center, Mannheim Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  4. 5

    Professor Emeritus of Medicine and Cardiology, Department of Cardiology and Angiology, Hospital of the University of Münster, Münster, Germany

  5. 6

    Chief, Cardiovascular Medicine Division, Director, Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service, Beth Israel Deaconess Medical Center, Herman C. Dana Professor of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA

Publication History

  1. Published Online: 18 DEC 2012
  2. Published Print: 10 JAN 2013

ISBN Information

Print ISBN: 9780470670460

Online ISBN: 9781118481585



  • atrial fibrillation;
  • pulmonary vein arrhythmogenicity;
  • autonomic modulation;
  • atrial electrograms;
  • time domain mapping;
  • renin-angiotensin-aldosterone system


Although pulmonary vein arrhythmogenicity plays a critical role in initiation and perpetuation of atrial fibrillation (AF) particularly in patients with paroxysmal AF, mechanisms beyond the pulmonary and other thoracic veins appear to be critical in perpetuation of AF. Among these mechanisms are the multiple wavelet hypothesis, autonomic modulation, and high frequency sources (rotors). In this chapter the role of frequency of mapping to eliminate high frequency sources is discussed in detail based on experimental data and clinical studies.