53. Diffusion Tensor Magnetic Resonance Imaging-Derived Myocardial Fiber Disarray in Hypertensive Left Ventricular Hypertrophy: Visualization, Quantification and the Effect on Mechanical Function

  1. Mohammad Shenasa MD5,
  2. Gerhard Hindricks MD6,
  3. Martin Borggrefe MD7,
  4. Günter Breithardt MD8 and
  5. Mark E. Josephson MD9
  1. Archontis Giannakidis1,
  2. Damien Rohmer2,
  3. Alexander I. Veress3 and
  4. Grant T. Gullberg1,4

Published Online: 18 DEC 2012

DOI: 10.1002/9781118481585.ch53

Cardiac Mapping, Fourth Edition

Cardiac Mapping, Fourth Edition

How to Cite

Giannakidis, A., Rohmer, D., Veress, A. I. and Gullberg, G. T. (2013) Diffusion Tensor Magnetic Resonance Imaging-Derived Myocardial Fiber Disarray in Hypertensive Left Ventricular Hypertrophy: Visualization, Quantification and the Effect on Mechanical Function, in Cardiac Mapping, Fourth Edition (eds M. Shenasa, G. Hindricks, M. Borggrefe, G. Breithardt and M. E. Josephson), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118481585.ch53

Editor Information

  1. 5

    Attending Physician, Department of Cardiovascular Services, O'Connor Hospital, Heart & Rhythm Medical Group, San Jose, California, USA

  2. 6

    Professor of Medicine (Cardiology), University Leipzig, Heart Center, Director, Department of Electrophysiology, Leipzig, Germany

  3. 7

    Professor of Medicine (Cardiology), Head, Department of Cardiology, Angiology and Pneumology, University Medical Center, Mannheim Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  4. 8

    Professor Emeritus of Medicine and Cardiology, Department of Cardiology and Angiology, Hospital of the University of Münster, Münster, Germany

  5. 9

    Chief, Cardiovascular Medicine Division, Director, Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service, Beth Israel Deaconess Medical Center, Herman C. Dana Professor of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. 1

    Lawrence Berkeley National Laboratory, Berkeley, CA, USA

  2. 2

    Lyon & Grenoble Université, CPE Lyon, Laboratoire Jean Kuntzmann, INRIA, France

  3. 3

    University of Washington, Seattle, WA, USA

  4. 4

    University of California San Francisco, San Francisco, CA, USA

Publication History

  1. Published Online: 18 DEC 2012
  2. Published Print: 10 JAN 2013

ISBN Information

Print ISBN: 9780470670460

Online ISBN: 9781118481585

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Keywords:

  • diffusion tensor MRI;
  • myocardium microstructure;
  • left ventricular hypertrophy;
  • hypertension;
  • myofiber disarray;
  • fiber tractography;
  • mechanical modeling;
  • rat heart

Summary

Left ventricular hypertrophy induced by systemic hypertension is generally regarded a morphological precursor of unfortunate cardiovascular events. Myocardial fiber disarray has been long recognized as a prevalent hallmark of this pathology. In this chapter, ex vivo diffusion tensor magnetic resonance imaging is employed to delineate the regional loss of myocardial organization that is present in the excised heart of a spontaneously hypertensive rat, as opposed to a control. Fiber tracking results are provided that illustrate in great detail the alterations in the integrity of cardiac muscle microstructure due to the disease. A quantitative analysis is also performed. Another contribution of this chapter is the model-based assessment of the role of the myofiber disarray in modulating the mechanical properties of the myocardium. The results of this study improve our understanding of the structural remodeling mechanisms that are associated with hypetensive left ventricular hypertrophy and their role.