54. Imaging Fiber Orientation with Optical Coherence Tomography and Diffusion-Tensor Magnetic Resonance Imaging and its Role in Arrhythmogenesis

  1. Mohammad Shenasa MD3,
  2. Gerhard Hindricks MD4,
  3. Martin Borggrefe MD5,
  4. Günter Breithardt MD6 and
  5. Mark E. Josephson MD7
  1. Rachel C. Myles1 and
  2. Crystal M. Ripplinger2

Published Online: 18 DEC 2012

DOI: 10.1002/9781118481585.ch54

Cardiac Mapping, Fourth Edition

Cardiac Mapping, Fourth Edition

How to Cite

Myles, R. C. and Ripplinger, C. M. (2013) Imaging Fiber Orientation with Optical Coherence Tomography and Diffusion-Tensor Magnetic Resonance Imaging and its Role in Arrhythmogenesis, in Cardiac Mapping, Fourth Edition (eds M. Shenasa, G. Hindricks, M. Borggrefe, G. Breithardt and M. E. Josephson), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118481585.ch54

Editor Information

  1. 3

    Attending Physician, Department of Cardiovascular Services, O'Connor Hospital, Heart & Rhythm Medical Group, San Jose, California, USA

  2. 4

    Professor of Medicine (Cardiology), University Leipzig, Heart Center, Director, Department of Electrophysiology, Leipzig, Germany

  3. 5

    Professor of Medicine (Cardiology), Head, Department of Cardiology, Angiology and Pneumology, University Medical Center, Mannheim Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  4. 6

    Professor Emeritus of Medicine and Cardiology, Department of Cardiology and Angiology, Hospital of the University of Münster, Münster, Germany

  5. 7

    Chief, Cardiovascular Medicine Division, Director, Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service, Beth Israel Deaconess Medical Center, Herman C. Dana Professor of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. 1

    British Heart Foundation, Cardiovascular Research Centre, University of Glasgow, Glasgow, UK

  2. 2

    University of California at Davis School of Medicine, Davis, CA, USA

Publication History

  1. Published Online: 18 DEC 2012
  2. Published Print: 10 JAN 2013

ISBN Information

Print ISBN: 9780470670460

Online ISBN: 9781118481585



  • fiber orientation;
  • optical coherence tomography;
  • diffusion-tensor magnetic resonance imaging;
  • arrhythmia


Cardiac fiber orientation is a major determinant of electrical wavefront propagation in the heart. Thus, it is critical to normal electrophysiological function and potentially important in arrhythmogenesis. Changes in fiber orientation and laminar structure occur during cardiac remodeling across a range of pathologies. An increasingly detailed knowledge of cardiac fiber orientation and its role in normal electrophysiological function has been gained using techniques such as OCT and DT-MRI in combination with electrophysiological techniques including optical mapping and computational modeling. These tools can now be used to probe the relationship between fiber orientation and the genesis of life-threatening ventricular arrhythmias.