58. Role of Mapping and Imaging in Brugada Syndrome

  1. Mohammad Shenasa MD3,
  2. Gerhard Hindricks MD4,
  3. Martin Borggrefe MD5,
  4. Günter Breithardt MD6 and
  5. Mark E. Josephson MD7
  1. Sergio Richter1,2 and
  2. Pedro Brugada1

Published Online: 18 DEC 2012

DOI: 10.1002/9781118481585.ch58

Cardiac Mapping, Fourth Edition

Cardiac Mapping, Fourth Edition

How to Cite

Richter, S. and Brugada, P. (2013) Role of Mapping and Imaging in Brugada Syndrome, in Cardiac Mapping, Fourth Edition (eds M. Shenasa, G. Hindricks, M. Borggrefe, G. Breithardt and M. E. Josephson), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118481585.ch58

Editor Information

  1. 3

    Attending Physician, Department of Cardiovascular Services, O'Connor Hospital, Heart & Rhythm Medical Group, San Jose, California, USA

  2. 4

    Professor of Medicine (Cardiology), University Leipzig, Heart Center, Director, Department of Electrophysiology, Leipzig, Germany

  3. 5

    Professor of Medicine (Cardiology), Head, Department of Cardiology, Angiology and Pneumology, University Medical Center, Mannheim Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  4. 6

    Professor Emeritus of Medicine and Cardiology, Department of Cardiology and Angiology, Hospital of the University of Münster, Münster, Germany

  5. 7

    Chief, Cardiovascular Medicine Division, Director, Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service, Beth Israel Deaconess Medical Center, Herman C. Dana Professor of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. 1

    Free University of Brussels, Brussels, Belgium

  2. 2

    University of Leipzig, Leipzig, Germany

Publication History

  1. Published Online: 18 DEC 2012
  2. Published Print: 10 JAN 2013

ISBN Information

Print ISBN: 9780470670460

Online ISBN: 9781118481585

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Keywords:

  • Brugada syndrome;
  • coved-type ST-segment elevation;
  • ventricular fibrillation;
  • premature ventricular contraction;
  • phase 2 reentry;
  • conduction abnormality;
  • right ventricular outflow tract;
  • mapping;
  • catheter ablation

Summary

Recent advances in genetics and molecular biology have made it possible to define a series of new diseases leading to cardiac arrhythmias: the channelopathies, such as Brugada syndrome. These diseases affect the structure and function of cardiac ion channels and result in atrial and ventricular tachyarrhythmias, disorders of impulse formation and conduction defects. These arrhythmogenic disorders are hereditary and in general occur in individuals with a structurally normal heart. Because there is no discrete lesion as substrate for the arrhythmias (as in myocardial infarction), mapping in channelopathies is confronted with very specific problems. The mechanism of arrhythmias and the challenges encountered while trying to map them in Brugada syndrome are discussed in this chapter.