68. Electrophysiological Implications of Myocardial Cell and Gene Therapy Strategies

  1. Mohammad Shenasa MD2,
  2. Gerhard Hindricks MD3,
  3. Martin Borggrefe MD4,
  4. Günter Breithardt MD5 and
  5. Mark E. Josephson MD6
  1. Leonid Maizels and
  2. Lior Gepstein

Published Online: 18 DEC 2012

DOI: 10.1002/9781118481585.ch68

Cardiac Mapping, Fourth Edition

Cardiac Mapping, Fourth Edition

How to Cite

Maizels, L. and Gepstein, L. (2013) Electrophysiological Implications of Myocardial Cell and Gene Therapy Strategies, in Cardiac Mapping, Fourth Edition (eds M. Shenasa, G. Hindricks, M. Borggrefe, G. Breithardt and M. E. Josephson), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118481585.ch68

Editor Information

  1. 2

    Attending Physician, Department of Cardiovascular Services, O'Connor Hospital, Heart & Rhythm Medical Group, San Jose, California, USA

  2. 3

    Professor of Medicine (Cardiology), University Leipzig, Heart Center, Director, Department of Electrophysiology, Leipzig, Germany

  3. 4

    Professor of Medicine (Cardiology), Head, Department of Cardiology, Angiology and Pneumology, University Medical Center, Mannheim Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  4. 5

    Professor Emeritus of Medicine and Cardiology, Department of Cardiology and Angiology, Hospital of the University of Münster, Münster, Germany

  5. 6

    Chief, Cardiovascular Medicine Division, Director, Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service, Beth Israel Deaconess Medical Center, Herman C. Dana Professor of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. Technion-Israel Institute of Technology, Haifa, Israel

Publication History

  1. Published Online: 18 DEC 2012
  2. Published Print: 10 JAN 2013

ISBN Information

Print ISBN: 9780470670460

Online ISBN: 9781118481585

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Keywords:

  • stem cells;
  • cell therapy;
  • gene therapy;
  • tissue engineering;
  • mapping;
  • arrhythmias;
  • biological pacemaker;
  • atrial fibrillation;
  • ventricular tachycardia

Summary

Recent advances in stem cell biology, molecular interventions and tissue engineering may allow the development of novel therapeutic paradigms for a variety of cardiac disorders. Here, we focus on the possible implications of these emerging strategies in the field of cardiac electrophysiology. Initially, the electrophysiological considerations associated with cell therapy for infarct repair are described, both from the mechanistic point of view (evaluating for electromechanical coupling) as well as from the therapeutic (prevention of ventricular arrhythmias) and potential adverse effects (increasing arrhythmogenesis) angles. Next, the experimental gene and cell therapy strategies being developed for the treatment of bradyarrhythmia and tachyarrhythmia are detailed. Specific emphasis will be placed on the potential role of various cardiac mapping and electrophysiological techniques in advancing this exciting new field.