72. Remodeling and Reverse Remodeling: Mapping/Imaging Findings

  1. Mohammad Shenasa MD3,
  2. Gerhard Hindricks MD4,
  3. Martin Borggrefe MD5,
  4. Günter Breithardt MD6 and
  5. Mark E. Josephson MD7
  1. Philippe Comtois1 and
  2. Stanley Nattel2

Published Online: 18 DEC 2012

DOI: 10.1002/9781118481585.ch72

Cardiac Mapping, Fourth Edition

Cardiac Mapping, Fourth Edition

How to Cite

Comtois, P. and Nattel, S. (2013) Remodeling and Reverse Remodeling: Mapping/Imaging Findings, in Cardiac Mapping, Fourth Edition (eds M. Shenasa, G. Hindricks, M. Borggrefe, G. Breithardt and M. E. Josephson), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118481585.ch72

Editor Information

  1. 3

    Attending Physician, Department of Cardiovascular Services, O'Connor Hospital, Heart & Rhythm Medical Group, San Jose, California, USA

  2. 4

    Professor of Medicine (Cardiology), University Leipzig, Heart Center, Director, Department of Electrophysiology, Leipzig, Germany

  3. 5

    Professor of Medicine (Cardiology), Head, Department of Cardiology, Angiology and Pneumology, University Medical Center, Mannheim Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  4. 6

    Professor Emeritus of Medicine and Cardiology, Department of Cardiology and Angiology, Hospital of the University of Münster, Münster, Germany

  5. 7

    Chief, Cardiovascular Medicine Division, Director, Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service, Beth Israel Deaconess Medical Center, Herman C. Dana Professor of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. 1

    Department of Physiology/Institute of Biomedical Engineering, University of Montreal, Montreal, QC, Canada; Montreal Heart Institute Research Center, Montreal, QC, Canada

  2. 2

    Department of Medicine, University of Montreal, Montreal, QC, Canada; Electrophysiology Research Program, Montreal Heart Institute Research Center, Montreal, QC, Canada

Publication History

  1. Published Online: 18 DEC 2012
  2. Published Print: 10 JAN 2013

ISBN Information

Print ISBN: 9780470670460

Online ISBN: 9781118481585



  • fibrosis;
  • conduction heterogeneities;
  • conduction velocities;
  • action potential duration;
  • atrial and ventricular arrhythmia;
  • structural and functional remodeling


The concept of cardiac remodeling and reverse remodeling as both a cause and an effect of cardiac pathophysiology is fundamental to understanding arrhythmogenesis. The arrhythmogenic potential is thought to come from structural and functional changes in properties. More and more evidence suggests that alteration in organ function can lead to modified structure and modified structure to altered function. This intricate “yin-yang” reveals the complex and continuous adaptation of the heart. In this chapter we review the diverse forms of remodeling and the limited remodeling found in different pathologies.