1. Living Donation: The Gold Standard

  1. Nizam Mamode2 and
  2. Raja Kandaswamy3
  1. Leonardo V. Riella and
  2. Anil Chandraker

Published Online: 23 DEC 2012

DOI: 10.1002/9781118483664.ch1

Abdominal Organ Transplantation: State of the Art

Abdominal Organ Transplantation: State of the Art

How to Cite

Riella, L. V. and Chandraker, A. (2013) Living Donation: The Gold Standard, in Abdominal Organ Transplantation: State of the Art (eds N. Mamode and R. Kandaswamy), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118483664.ch1

Editor Information

  1. 2

    Guy's and St Thomas' Hospital, Great Ormond Street Hospital, London, UK

  2. 3

    Department of Surgery, University of Minnesota, Minneapolis, MN, USA

Author Information

  1. Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Publication History

  1. Published Online: 23 DEC 2012
  2. Published Print: 12 FEB 2013

ISBN Information

Print ISBN: 9781444334326

Online ISBN: 9781118483664

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Keywords:

  • living-donor transplantation;
  • live donor;
  • end-stage kidney disease;
  • ESKD

Summary

The introduction of immunosuppressive drugs such as azathioprine, prednisone, and later calcineurin inhibitors has led to better transplant outcomes and, along with technical breakthroughs, expanded the pool of organs available to deceased and human leukocyte antigen (HLA) -mismatched donors. Kidney transplantation has become the preferred therapeutic option for patients with end-stage kidney disease (ESKD), leading to better patient survival and quality of life. It is also more cost-effective than dialysis. Unfortunately, the incidence of ESKD has risen steadily in the past several decades, creating a shortage of available organs for patients on the kidney-transplant waiting list. This growth in ESKD is related to the increased incidence of diabetes, obesity, and hypertension, combined with the improvement in treatment for concurrent health problems such as ischemic heart disease and stroke. The supply of organs from deceased donors has not followed the same upward trend, resulting in an ever-widening gap between eligible potential transplant recipients and available organs.