6. Allotransplantation of Pancreatic Islets

  1. Nizam Mamode4 and
  2. Raja Kandaswamy5
  1. Maciej T. Juszczak1 and
  2. Paul R. V. Johnson2,3

Published Online: 23 DEC 2012

DOI: 10.1002/9781118483664.ch6

Abdominal Organ Transplantation: State of the Art

Abdominal Organ Transplantation: State of the Art

How to Cite

Juszczak, M. T. and Johnson, P. R. V. (2013) Allotransplantation of Pancreatic Islets, in Abdominal Organ Transplantation: State of the Art (eds N. Mamode and R. Kandaswamy), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118483664.ch6

Editor Information

  1. 4

    Guy's and St Thomas' Hospital, Great Ormond Street Hospital, London, UK

  2. 5

    Department of Surgery, University of Minnesota, Minneapolis, MN, USA

Author Information

  1. 1

    Islet Transplant Programme, Oxford Centre for Diabetes, Endocrinology and Metabolism, and Islet Transplant Research Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

  2. 2

    John Radcliffe Hospital, UK

  3. 3

    St Edmund Hall, University of Oxford, UK

Publication History

  1. Published Online: 23 DEC 2012
  2. Published Print: 12 FEB 2013

ISBN Information

Print ISBN: 9781444334326

Online ISBN: 9781118483664

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Keywords:

  • islet transplantation;
  • pancreas;
  • islet cell;
  • allotransplantation;
  • type-1 diabetes mellitus;
  • T1DM;
  • immunosuppression

Summary

SLET transplantation has become a recognised treatment for brittle Type 1 Diabetes Mellitus. Indeed, the short and mid-term results for this treatment are now equivalent to those achieved with vascularised pancreas transplants. It is therefore important for the transplant clinician to be familiar with the different aspects of this therapy. This chapter provides an overall summary of islet transplantation, including donor selection, islet isolation, recipient selection and work-up, the transplant itself, and the post-operative management and outcomes.