8. Intestinal Transplantation

  1. Nizam Mamode3 and
  2. Raja Kandaswamy4
  1. Khalid M. Khan1,
  2. Tun Jie2,
  3. Chirag S. Desai2 and
  4. Rainer W. G. Gruessner2

Published Online: 23 DEC 2012

DOI: 10.1002/9781118483664.ch8

Abdominal Organ Transplantation: State of the Art

Abdominal Organ Transplantation: State of the Art

How to Cite

Khan, K. M., Jie, T., Desai, C. S. and Gruessner, R. W. G. (2013) Intestinal Transplantation, in Abdominal Organ Transplantation: State of the Art (eds N. Mamode and R. Kandaswamy), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118483664.ch8

Editor Information

  1. 3

    Guy's and St Thomas' Hospital, Great Ormond Street Hospital, London, UK

  2. 4

    Department of Surgery, University of Minnesota, Minneapolis, MN, USA

Author Information

  1. 1

    Pediatric Liver & Intestine Transplant Program, University of Arizona, Tucson, AZ, USA

  2. 2

    Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA

Publication History

  1. Published Online: 23 DEC 2012
  2. Published Print: 12 FEB 2013

ISBN Information

Print ISBN: 9781444334326

Online ISBN: 9781118483664

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Keywords:

  • intestinal transplantation;
  • ITx;
  • multivisceral transplant;
  • liver–intestine transplant;
  • isolated intestinal transplant

Summary

Continuity with its environment makes the intestine a unique abdominal organ. Apart from its nutritional role, it contains a large amount of lymphoid tissue and intimately interacts with microbial flora. The lymphoid element within the gut has a necessary, complex immunological role, so it was always deemed an intuitive barrier to intestinal transplantation. Nevertheless, Richard Lillehei at the University of Minnesota saw the potential for transplanting the small intestine in patients with intestinal failure and performed the first such transplant in the 1960s. Early refinements in surgical technique were followed by advances in immunosuppression and a better appreciation of post-transplant care; today, an intestinal transplant (ITx) is a well-established option in clinical practice.