2. Mycosis Fungoides

  1. Lorenzo Cerroni MD

Published Online: 24 APR 2014

DOI: 10.1002/9781118492505.ch2

Skin Lymphoma: The Illustrated Guide, Fourth Edition

Skin Lymphoma: The Illustrated Guide, Fourth Edition

How to Cite

Cerroni, L. (ed) (2014) Mycosis Fungoides, in Skin Lymphoma: The Illustrated Guide, Fourth Edition, John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118492505.ch2

Editor Information

  1. Director, Cutaneous Lymphoma Unit, Director, Dermatopathology Research Center, Department of Dermatology, Medical University of Graz, Graz, Austria

Publication History

  1. Published Online: 24 APR 2014
  2. Published Print: 23 MAY 2014

ISBN Information

Print ISBN: 9781118492499

Online ISBN: 9781118492505

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Keywords:

  • extracutaneous involvement;
  • hematological diseases;
  • molecular genetics;
  • mycosis fungoides;
  • mycosis fungoides diagnosis

Summary

One of the main subjects of discussion in mycosis fungoides is the relationship with the so-called “parapsoriases”. Lymph nodes, lung, spleen and liver are the most frequent sites of extracutaneous involvement in mycosis fungoides, but specific lesions can arise in all organs. Mycosis fungoides can be observed in association with other hematological diseases such as lymphomatoid papulosis, anaplastic large cell lymphoma, and Hodgkin lymphoma. Scoring systems and algorithms for the diagnosis of mycosis fungoides have been proposed, combining the clinical aspect with the immunophenotypic and molecular features of the infiltrate. Epidermotropism of solitary lymphocytes is usually found, but Darier's nests (Pautrier's microabscesses) are rare. Molecular analysis of early lesions of mycosis fungoides is hindered by the intrinsic difficulties in the identification of neoplastic cells, which are a small minority and may look morphologically and phenotypically identical to reactive lymphocytes.