15. Extraction-Fermentation Hybrid (Extractive Fermentation)

  1. Shri Ramaswamy3,
  2. Hua-Jiang Huang3 and
  3. Bandaru V. Ramarao4
  1. Shang-Tian Yang1 and
  2. Congcong Lu2

Published Online: 4 MAR 2013

DOI: 10.1002/9781118493441.ch15

Separation and Purification Technologies in Biorefineries

Separation and Purification Technologies in Biorefineries

How to Cite

Yang, S.-T. and Lu, C. (2013) Extraction-Fermentation Hybrid (Extractive Fermentation), in Separation and Purification Technologies in Biorefineries (eds S. Ramaswamy, H.-J. Huang and B. V. Ramarao), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118493441.ch15

Editor Information

  1. 3

    Department of Bioproducts and Biosystems Engineering, University of Minnesota, Saint Paul, Minnesota, USA

  2. 4

    Department of Paper and Bioprocess Engineering, Empire State Paper Research Institute, State University of New York College of Environmental Science and Forestry, Syracuse, New York, USA

Author Information

  1. 1

    William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA

  2. 2

    Coatings Technology Center, DCM, The Down Chemical Company, Midland, Michigan, USA

Publication History

  1. Published Online: 4 MAR 2013
  2. Published Print: 11 FEB 2013

ISBN Information

Print ISBN: 9780470977965

Online ISBN: 9781118493441



  • biobutanol production;
  • biorefinery industry;
  • butyric acid;
  • extractive fermentation;
  • separation technology;
  • slip-stream approach


This chapter on extraction-fermentation hybrid (extractive fermentation) reviews recent advances in separation technologies that can be used in the slip-stream approach for in situ recovery of fermentation products, focusing on carboxylic acids and alcohols. First, the chapter provides an introduction to industrial needs for integrated fermentation-separation processes and their benefits to the biorefinery industry. A brief description of the basic principles of extractive fermentation and more detailed discussion of the design and operation of various in situ product recovery techniques follws. Finally, two extractive fermentation examples are illustrated, one for biobutanol production and the other for butyric acid production by Clostridia. Both of them are still at the laboratory-scale research and development stage, but hold great promise for industrial application. Lastly, a conclusion and some perspectives about the future trend in this technology area are provided.