7. Simulated Moving-Bed Technology for Biorefinery Applications

  1. Shri Ramaswamy3,
  2. Hua-Jiang Huang3 and
  3. Bandaru V. Ramarao4
  1. Chim Yong Chin1 and
  2. Nien-Hwa Linda Wang2

Published Online: 4 MAR 2013

DOI: 10.1002/9781118493441.ch7

Separation and Purification Technologies in Biorefineries

Separation and Purification Technologies in Biorefineries

How to Cite

Chin, C. Y. and Wang, N.-H. L. (2013) Simulated Moving-Bed Technology for Biorefinery Applications, in Separation and Purification Technologies in Biorefineries (eds S. Ramaswamy, H.-J. Huang and B. V. Ramarao), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118493441.ch7

Editor Information

  1. 3

    Department of Bioproducts and Biosystems Engineering, University of Minnesota, Saint Paul, Minnesota, USA

  2. 4

    Department of Paper and Bioprocess Engineering, Empire State Paper Research Institute, State University of New York College of Environmental Science and Forestry, Syracuse, New York, USA

Author Information

  1. 1

    PureVision Technology, Inc., Ft. Lupton, Colorado, USA

  2. 2

    School of Chemical Engineering, Purdue University, West Lafayette, Indiana, USA

Publication History

  1. Published Online: 4 MAR 2013
  2. Published Print: 11 FEB 2013

ISBN Information

Print ISBN: 9780470977965

Online ISBN: 9781118493441



  • biorefinery applications;
  • purification technology;
  • separation technology;
  • simulated moving-bed (SMB) technology;
  • supercritical fluid chromatography


Simulated moving-bed (SMB) technology is a continuous separation technique that improves upon traditional batch chromatography. This chapter provides an introduction with an overview of the principles of SMB, its essential design tools, and several examples of potential SMB applications in biorefineries. SMB is being applied in at least one commercial biorefinery demonstration. The authors have seen significant interest from other biorefinery developers and expect SMB technology to play an important role in future biorefineries. Advances in the future are expected in the application of supercritical fluid chromatography in SMB, especially supercritical carbon dioxide, and in the integration of SMB with other separation techniques. These advances will include crystallization and distillation operations between SMB zones. The authors also expect SMB reactors to see significant development in the future and the use of SMB principles in other unit operations.