18. Biomarkers

  1. Ingvar Eidhammer,
  2. Harald Barsnes,
  3. Geir Egil Eide and
  4. Lennart Martens

Published Online: 10 JAN 2013

DOI: 10.1002/9781118494042.ch18

Computational and Statistical Methods for Protein Quantification by Mass Spectrometry

Computational and Statistical Methods for Protein Quantification by Mass Spectrometry

How to Cite

Eidhammer, I., Barsnes, H., Eide, G. E. and Martens, L. (2013) Biomarkers, in Computational and Statistical Methods for Protein Quantification by Mass Spectrometry, John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9781118494042.ch18

Publication History

  1. Published Online: 10 JAN 2013
  2. Published Print: 4 JAN 2013

ISBN Information

Print ISBN: 9781119964001

Online ISBN: 9781118494042

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Keywords:

  • biomarkers;
  • threshold values

Summary

A biomarker is typically considered as a particular biological molecule that indicates a particular biological or pathological state, or that can be used to assess the response of an organism to a treatment. This chapter describes the threshold values for potential biomarkers. In the evaluation of biomarkers it is important to take the occurrence rate of the disease, d, referred to as the disease prevalence, into account. In general, diseases with very low prevalence are much harder to detect reliably than diseases with a high prevalence.

Controlled Vocabulary Terms

Computational statistics; Inferential statistics