2. Correlations of mRNA and Protein Abundances

  1. Ingvar Eidhammer,
  2. Harald Barsnes,
  3. Geir Egil Eide and
  4. Lennart Martens

Published Online: 10 JAN 2013

DOI: 10.1002/9781118494042.ch2

Computational and Statistical Methods for Protein Quantification by Mass Spectrometry

Computational and Statistical Methods for Protein Quantification by Mass Spectrometry

How to Cite

Eidhammer, I., Barsnes, H., Eide, G. E. and Martens, L. (2013) Correlations of mRNA and Protein Abundances, in Computational and Statistical Methods for Protein Quantification by Mass Spectrometry, John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9781118494042.ch2

Publication History

  1. Published Online: 10 JAN 2013
  2. Published Print: 4 JAN 2013

ISBN Information

Print ISBN: 9781119964001

Online ISBN: 9781118494042

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Keywords:

  • codon bias;
  • mRNA;
  • protein abundances

Summary

This chapter discusses the correlation between mRNA abundance and protein abundance. Codon bias is a measure of the tendency of an organism to prefer certain nucleotide codons over others when more than one codon encodes for the same amino acid in a gene sequence. Numerous experiments have been performed to investigate the relation between mRNA and protein abundance, and a general correlation has been detected. It is however not strong enough to be used for individual proteins. The chapter briefly describes different types of correlation experiments for mRNA-protein abundances. The following entities are used in the description: gene, individual (or species), site, state, time point. The chapter considers mRNA abundances and protein abundances from two samples taken from two comparable conditions, for example, from two species or from two sites, or from two cell lines.

Controlled Vocabulary Terms

Computational statistics; Inferential statistics