12. Adipose Tissue–Derived Stem Cells and Their Regeneration Potential

  1. George T.-J. Huang3 and
  2. Irma Thesleff4
  1. Jeffrey Gimble1,
  2. Maryam Rezai Rad2 and
  3. Shaomian Yao2

Published Online: 26 MAR 2013

DOI: 10.1002/9781118498026.ch12

Stem Cells in Craniofacial Development and Regeneration

Stem Cells in Craniofacial Development and Regeneration

How to Cite

Gimble, J., Rad, M. R. and Yao, S. (2013) Adipose Tissue–Derived Stem Cells and Their Regeneration Potential, in Stem Cells in Craniofacial Development and Regeneration (eds G. T.-J. Huang and I. Thesleff), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118498026.ch12

Editor Information

  1. 3

    Department of Bioscience Research, College of Dentistry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA

  2. 4

    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland

Author Information

  1. 1

    Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA

  2. 2

    Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA

Publication History

  1. Published Online: 26 MAR 2013
  2. Published Print: 22 MAR 2013

ISBN Information

Print ISBN: 9781118279236

Online ISBN: 9781118498026



  • adipose tissue–derived stem cells;
  • ASCs;
  • craniofacial preclinical animal models;
  • dental tissue regeneration;
  • stromal vascular fraction cells


This chapter reviews the in vitro and in vivo characterization of adipose-derived cells and recent advances of craniofacial repair and regeneration using adipose tissue–derived stromal and stem cells (ASCs) in both preclinical and human models. The potential of ASCs for dental tissue regeneration is also discussed. The use of adipose-derived cells (stromal vascular fraction (SVF) cells and ASCs) and matrices for craniofacial regeneration is still in its infancy from a clinical perspective. The use of adipose tissue as an autologous or allogeneic resource holds substantial promise. It will be important to define the mechanisms responsible for the contribution of SVF cells and ASCs to regeneration at the signal transduction and/or differentiation levels. This information may lead to improved combinations of growth factors and/or osteo-inductive and osteo—conductive matrices to accelerate repair.