16. Mesenchymal Stem Cells: Application for Immunomodulation and Tissue Repair

  1. Ruth M. Warwick MB, ChB, FRCP, FRCPath5 and
  2. Scott A. Brubaker CTBS6
  1. Nicole J. Horwood PhD1,
  2. Francesco Dazzi MD, PhD2,
  3. Walid Zaher MD, MSc, MHPE3,4 and
  4. Moustapha Kassem MD4

Published Online: 2 AUG 2012

DOI: 10.1002/9781118498453.ch16

Tissue and Cell Clinical Use: An Essential Guide

Tissue and Cell Clinical Use: An Essential Guide

How to Cite

Horwood, N. J., Dazzi, F., Zaher, W. and Kassem, M. (2012) Mesenchymal Stem Cells: Application for Immunomodulation and Tissue Repair, in Tissue and Cell Clinical Use: An Essential Guide (eds R. M. Warwick and S. A. Brubaker), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118498453.ch16

Editor Information

  1. 5

    University of Bristol, Bristol, UK

  2. 6

    American Association of Tissue Banks, McLean, VA, USA

Author Information

  1. 1

    University of Oxford, London, UK

  2. 2

    Department of Medicine, Imperial College, London, UK

  3. 3

    King Saud University, Riyadh, Kingdom of Saudi Arabia

  4. 4

    University Hospital of Odense, Odense, Denmark

Publication History

  1. Published Online: 2 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781405198257

Online ISBN: 9781118498453

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Keywords:

  • mesenchymal stem cells;
  • immunosuppression;
  • tissue engineering;
  • graft versus host disease

Summary

Mesenchymal stem cells (MSC) are stem cell populations present among the bone marrow stroma and a number of other tissues that are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts, adipocytes and chondrocytes. MSC provide supportive stroma for growth and differentiation of hematopoietic stem cells (HSC) and hematopoiesis. These cells have been described as important immunoregulators due to their ability to suppress T cells proliferation. MSC can also directly contribute to tissue repair by migrating to sites of injury and providing a source of cells for differentiation and/or providing bystander support for resident stromal cells. This chapter discusses the cellular and molecular properties of MSC, the mechanisms by which they can modulate immune responses and the clinical applications of MSC in disorders such as graft-versus-host disease and aplastic anaemia. The role of MSC in the treatment of autoimmune disorders as well as their potential in the arena of tissue repair and a view of what the future clinical applications of MSC might be is outlined in this chapter.