10. Imaging Mass Spectrometry of Proteins and Peptides

  1. Walter A. Korfmacher
  1. Michelle L. Reyzer and
  2. Richard M. Caprioli

Published Online: 17 JAN 2013

DOI: 10.1002/9781118516157.ch10

Mass Spectrometry for Drug Discovery and Drug Development

Mass Spectrometry for Drug Discovery and Drug Development

How to Cite

Reyzer, M. L. and Caprioli, R. M. (2013) Imaging Mass Spectrometry of Proteins and Peptides, in Mass Spectrometry for Drug Discovery and Drug Development (ed W. A. Korfmacher), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118516157.ch10

Editor Information

  1. Genzyme, a SANOFI Company, Waltham, MA, USA

Author Information

  1. Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA

Publication History

  1. Published Online: 17 JAN 2013
  2. Published Print: 22 JAN 2013

Book Series:

  1. Wiley Series on Mass Spectrometry

Book Series Editors:

  1. Dominic M. Desiderio3 and
  2. Nico M. M. Nibbering4

Series Editor Information

  1. 3

    Departments of Neurology and Biochemistry, University of Tennessee Health Science Center, USA

  2. 4

    Vrije Universiteit Amsterdam, The Netherlands

ISBN Information

Print ISBN: 9780470942383

Online ISBN: 9781118516157

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Keywords:

  • IMS, molecular pathology in human health;
  • protein/peptide studies, and IMS impact;
  • IMS full tissue image/targeted profiling;
  • intact protein analysis, and applications;
  • digested peptide analysis, in situ digestion

Summary

This chapter contains sections titled:

  • Introduction

  • Methodology

  • Intact Protein Analysis: Applications

  • Peptide Analysis: Digested Peptides

  • Peptide Analysis: Intact Endogenous Peptides

  • Conclusions

  • Acknowledgments

  • References