2. Utility of High-Resolution Mass Spectrometry for New Drug Discovery Applications

  1. Walter A. Korfmacher
  1. William Bart Emary and
  2. Nanyan Rena Zhang

Published Online: 17 JAN 2013

DOI: 10.1002/9781118516157.ch2

Mass Spectrometry for Drug Discovery and Drug Development

Mass Spectrometry for Drug Discovery and Drug Development

How to Cite

Bart Emary, W. and Zhang, N. R. (2013) Utility of High-Resolution Mass Spectrometry for New Drug Discovery Applications, in Mass Spectrometry for Drug Discovery and Drug Development (ed W. A. Korfmacher), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118516157.ch2

Editor Information

  1. Genzyme, a SANOFI Company, Waltham, MA, USA

Author Information

  1. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co. Inc., West Point, PA, USA

Publication History

  1. Published Online: 17 JAN 2013
  2. Published Print: 22 JAN 2013

Book Series:

  1. Wiley Series on Mass Spectrometry

Book Series Editors:

  1. Dominic M. Desiderio3 and
  2. Nico M. M. Nibbering4

Series Editor Information

  1. 3

    Departments of Neurology and Biochemistry, University of Tennessee Health Science Center, USA

  2. 4

    Vrije Universiteit Amsterdam, The Netherlands

ISBN Information

Print ISBN: 9780470942383

Online ISBN: 9781118516157

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Keywords:

  • HRMS, for new drug discovery applications;
  • pharmaceutical industry and HRMS;
  • drug metabolism, qualitative/quantitative;
  • toxicity, and biochemical biomarker link;
  • new analytical instrumentation

Summary

This chapter contains sections titled:

  • Introduction

  • Qualitative/Quantitative Workflow in Drug Metabolism

  • Biomarkers

  • Tissue

  • siRNA and Protein Therapies

  • Drug Metabolite Identification Using Mass Defect Filters

  • Future Trends

  • Conclusions

  • Acknowledgments

  • References