8. Liquid Extraction Surface Analysis (LESA): A New Mass Spectrometry-Based Technique for Ambient Surface Profiling

  1. Walter A. Korfmacher
  1. Daniel Eikel and
  2. Jack D. Henion

Published Online: 17 JAN 2013

DOI: 10.1002/9781118516157.ch8

Mass Spectrometry for Drug Discovery and Drug Development

Mass Spectrometry for Drug Discovery and Drug Development

How to Cite

Eikel, D. and Henion, J. D. (2013) Liquid Extraction Surface Analysis (LESA): A New Mass Spectrometry-Based Technique for Ambient Surface Profiling, in Mass Spectrometry for Drug Discovery and Drug Development (ed W. A. Korfmacher), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118516157.ch8

Editor Information

  1. Genzyme, a SANOFI Company, Waltham, MA, USA

Author Information

  1. Advion, Ithaca, NY, USA

Publication History

  1. Published Online: 17 JAN 2013
  2. Published Print: 22 JAN 2013

Book Series:

  1. Wiley Series on Mass Spectrometry

Book Series Editors:

  1. Dominic M. Desiderio3 and
  2. Nico M. M. Nibbering4

Series Editor Information

  1. 3

    Departments of Neurology and Biochemistry, University of Tennessee Health Science Center, USA

  2. 4

    Vrije Universiteit Amsterdam, The Netherlands

ISBN Information

Print ISBN: 9780470942383

Online ISBN: 9781118516157

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Keywords:

  • LESA, ambient profiling, LESA MS in MSI;
  • MS and surface, overcoming QWBA limitations;
  • fluticasone MS/MS fragmentation;
  • LESA in fruit/vegetable pesticide identification;
  • LESA, analyte extraction/ionization optimization

Summary

This chapter contains sections titled:

  • Introduction

  • LESA: How Does It Work?

  • Examples of LESA Applications in Drug Development and Drug Discovery

  • LESA Applications beyond Drug Development and Drug Discovery

  • Outlook and Future Development of LESA

  • Conclusions

  • References