39. Stem Cell Collection and Therapeutic Apheresis

  1. Michael F. Murphy MD, FRCP, FrcPath3,4,
  2. Derwood H. Pamphilon MD, MRCPCH, FRCP, FrcPath5,6 and
  3. Nancy M. Heddle MSc, FCSMLS(D)7
  1. Khaled El-Ghariani1 and
  2. Zbigniew M. Szczepiorkowski2

Published Online: 26 FEB 2013

DOI: 10.1002/9781118520093.ch39

Practical Transfusion Medicine, Fourth Edition

Practical Transfusion Medicine, Fourth Edition

How to Cite

El-Ghariani, K. and Szczepiorkowski, Z. M. (2013) Stem Cell Collection and Therapeutic Apheresis, in Practical Transfusion Medicine, Fourth Edition (eds M. F. Murphy, D. H. Pamphilon and N. M. Heddle), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118520093.ch39

Editor Information

  1. 3

    Professor of Blood Transfusion Medicine University of Oxford;

  2. 4

    Consultant Haematologist NHS Blood and Transplant and Department of Haematology John Radcliffe Hospital Oxford, UK

  3. 5

    Formerly, Consultant Haematologist NHS Blood and Transplant Bristol, UK;

  4. 6

    Honorary Clinical Reader Department of Cellular and Molecular Medicine University of Bristol Bristol, UK

  5. 7

    Director, MTRP Professor, Department of Medicine McMaster University Canadian Blood Services Hamilton, ON, Canada

Author Information

  1. 1

    NHS Blood and Transplant and Sheffield Teaching Hospitals NHS Trust and University of Sheffield, Sheffield, UK

  2. 2

    Transfusion Medicine Service, Cellular Therapy Center, Dartmouth-Hitchcock Medical Centre and Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

Publication History

  1. Published Online: 26 FEB 2013
  2. Published Print: 10 MAR 2013

ISBN Information

Print ISBN: 9780470670514

Online ISBN: 9781118520093

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Keywords:

  • Apheresis;
  • plasma exchange;
  • red cell exchange;
  • stem cell mobilization;
  • stem cell donation;
  • poor mobilizers;
  • G-CSF;
  • plerixafor;
  • photopheresis

Summary

Apheresis machines are used to deliver a wide range of treatments to patients. Peripheral blood stem cells, mobilized by G-CSF chemotherapy, have become the primary source of grafts in haemopoietic stem cell transplantation. Poor mobilizers require skilled management and the recent introduction of plerixafor has increased the chances of successful mobilizations in this group of donors. Evidence supporting, or otherwise, the use of plasma exchange to treat various disorders is accumulating. Photopheresis is increasingly being used to treat cutaneous lymphoma and GVHD. Therapeutic apheresis can be associated with complications and patient inconvenience, and these require attention by skilled operators.