2. Transcriptome Profiling of Drosophila Interspecific Hybrids: Insights into Mechanisms of Regulatory Divergence and Hybrid Dysfunction

  1. Z. Jeffrey Chen3 and
  2. James A. Birchler4
  1. José M. Ranz1,
  2. Shu-Dan Yeh1,
  3. Kevin G. Nyberg2 and
  4. Carlos A. Machado2

Published Online: 4 APR 2013

DOI: 10.1002/9781118552872.ch2

Polyploid and Hybrid Genomics

Polyploid and Hybrid Genomics

How to Cite

Ranz, J. M., Yeh, S.-D., Nyberg, K. G. and Machado, C. A. (2013) Transcriptome Profiling of Drosophila Interspecific Hybrids: Insights into Mechanisms of Regulatory Divergence and Hybrid Dysfunction, in Polyploid and Hybrid Genomics (eds Z. J. Chen and J. A. Birchler), John Wiley & Sons, Inc., Oxford, UK. doi: 10.1002/9781118552872.ch2

Editor Information

  1. 3

    The University of Texas at Austin, Austin, Texas

  2. 4

    University of Missouri, Columbia, Missouri

Author Information

  1. 1

    Department of Ecology and Evolutionary Biology, University of California, Irvine, California, USA

  2. 2

    Department of Biology, University of Maryland, College Park, Maryland, USA

Publication History

  1. Published Online: 4 APR 2013
  2. Published Print: 14 MAY 2013

ISBN Information

Print ISBN: 9780470960370

Online ISBN: 9781118552872

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Keywords:

  • Expression profiling;
  • evolution of gene expression;
  • regulatory incompatibilities;
  • misexpression;
  • interspecific hybrids;
  • speciation

Summary

Studies of Drosophila interspecific hybrids have provided unique and important insights into research areas as diverse as those addressing the genetic basis of speciation or the genetic basis of gene expression divergence. Here, we thoroughly review the literature on gene-specific and genome-wide surveys of gene expression in Drosophila interspecific hybrids. We discuss how expression divergence between species leads to transcription network disruption in hybrids in the context of a variety of organismal traits including regulation of gene expression, ontogeny, sex differences, interspecific genomic mismatches, and phenotypic hybrid dysfunction. We argue that ongoing technical developments in transcriptome characterization coupled with classical genetic approaches are poised to improve our understanding of the process of species formation and differentiation in model and nonmodel Drosophila species.