4. Oxidative Stress in Neurodegenerative Diseases

  1. Robert Crichton and
  2. Roberta Ward

Published Online: 6 SEP 2013

DOI: 10.1002/9781118553480.ch04

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

How to Cite

Crichton, R. and Ward, R. (eds) (2013) Oxidative Stress in Neurodegenerative Diseases, in Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, John Wiley and Sons Ltd, Chichester, United Kingdom. doi: 10.1002/9781118553480.ch04

Editor Information

  1. Unit of Biochemistry, Université Catholique de Louvain, Belgium

Publication History

  1. Published Online: 6 SEP 2013
  2. Published Print: 25 OCT 2013

ISBN Information

Print ISBN: 9781119977148

Online ISBN: 9781118553480

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Keywords:

  • cellular defence mechanism;
  • cellular signalling;
  • neurodegenerative diseases;
  • oxidative damage;
  • oxidative stress;
  • reactive nitrogen species (RNS);
  • reactive oxygen species (ROS)

Summary

As a necessary consequence of the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), aerobic organisms, from man to microbe, have developed an elaborate system of cytoprotection against oxidative stress. Most living organisms have a system of defences, which is both elaborate and redundant, to protect them from the potential damage that can be inflicted by both ROS and RNS. Proteins which are involved in metabolism and signalling are regulated by posttranslational modifications that influence their catalytic activity, rates of turnover and targeting to subcellular locations. A common hallmark of many neurodegenerative diseases and indeed of a number of other diseases such as type 2 diabetes is the presence of proteinaceous deposits in the affected tissues and organs, which, in some cases, are believed to be the main causative agents of the clinical symptoms.