5. Ageing and Mild Cognitive Impairment (MCI)

  1. Robert Crichton and
  2. Roberta Ward

Published Online: 6 SEP 2013

DOI: 10.1002/9781118553480.ch05

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

How to Cite

Crichton, R. and Ward, R. (eds) (2013) Ageing and Mild Cognitive Impairment (MCI), in Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, John Wiley and Sons Ltd, Chichester, United Kingdom. doi: 10.1002/9781118553480.ch05

Editor Information

  1. Unit of Biochemistry, Université Catholique de Louvain, Belgium

Publication History

  1. Published Online: 6 SEP 2013
  2. Published Print: 25 OCT 2013

ISBN Information

Print ISBN: 9781119977148

Online ISBN: 9781118553480

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Keywords:

  • ageing;
  • epigenetics;
  • genetics;
  • mild cognitive impairment (MCI)

Summary

Ageing is a complex process, and occurs as a consequence of unsuccessful cell maintenance and impaired mitochondrial function. Genetics and epigenetics changes may contribute to a longer or shorter life expectancy. With advancing ageing, there is a decline in both performance and fitness, which is exhibited as frailty (loss of physiological processes and changes in metabolism) as well as cognitive decline. Cognitive changes are characterized by loss of memory, confusion as well as agitation. Mild cognitive impairment (MCI), incipient dementia or isolated memory impairment is a brain function syndrome, which involves the onset of cognitive impairment beyond those which might be expected considering the age and education of the individual. This chapter has identified a number of pathways which may enhance lifespan; which include decreased signalling of insulin/insulin-like growth factor ((IGF)-1), an increase expression of sirtuins, increased telomere length and modestly decreased mitochondrial function.