6. Parkinson's Disease

  1. Robert Crichton and
  2. Roberta Ward

Published Online: 6 SEP 2013

DOI: 10.1002/9781118553480.ch06

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

How to Cite

Crichton, R. and Ward, R. (eds) (2013) Parkinson's Disease, in Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, John Wiley and Sons Ltd, Chichester, United Kingdom. doi: 10.1002/9781118553480.ch06

Editor Information

  1. Unit of Biochemistry, Université Catholique de Louvain, Belgium

Publication History

  1. Published Online: 6 SEP 2013
  2. Published Print: 25 OCT 2013

ISBN Information

Print ISBN: 9781119977148

Online ISBN: 9781118553480

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Keywords:

  • DJ-1;
  • inflammation;
  • leucine-rich repeat kinase 2 (LRRK2);
  • mitochondrial dysfunction;
  • oxidative stress;
  • Parkin;
  • Parkinson's disease (PD);
  • PTEN-induced putative kinase 1 (PINK1);
  • SNCA

Summary

Parkinson's disease (PD) is possibly multifactorial, with input from a variety of genetic, environmental and endotoxin factors. The increased iron content in the substantia nigra (SN), oxidative stress and inflammation, abnormal protein turnover and degradation as well as mitochondrial dysfunction are all key factors in the development and progression of this disease. This chapter talks about risk factors for PD. Only 10% of PD cases are early onset, <50 years, and occur within specific family clusters and are caused by mutations in specific genes such as SNCA, Parkin, leucine-rich repeat kinase 2 (LRRK2), PTEN-induced putative kinase 1 (PINK1) and DJ-1. Epigenetic modifications may be important factors in the development of PD, by contributing to the disease pathogenesis. The chapter describes proteins, metals and neurotransmitters are involved in PD. It discusses mitochondrial dysfunction, which is a major causative factor in PD. The chapter deals with receptors involved in the inflammatory response.