6. Lithium, Thyroid Hormones and Further Augmentation Strategies in Treatment-resistant Depression
Published Online: 5 FEB 2013
Copyright © 2013 John Wiley & Sons, Ltd.
How to Cite
Kasper, S. and Montgomery, S. (2013) Lithium, Thyroid Hormones and Further Augmentation Strategies in Treatment-resistant Depression, in Treatment-resistant Depression, John Wiley & Sons, Oxford. doi: 10.1002/9781118556719.ch6
- Published Online: 5 FEB 2013
- Published Print: 8 APR 2013
Print ISBN: 9781119952909
Online ISBN: 9781118556719
- thyroid hormones
A variety of pharmacologically different nonantidepressant agents have been studied for their ability to augment the efficacy of antidepressants in depressed patients who do not respond sufficiently. Among the strategies reviewed in this chapter, augmentation with lithium is the best-evidenced, showing clear efficacy in a metaanalysis of 10 placebo-controlled trials. All other commonly used augmentation strategies described in this chapter are not well supported by sufficient data from randomised controlled trials (RCTs). There is also a lack of controlled comparator studies with different augmentation agents. Such studies are needed to better guide physicians in the treatment of nonresponders to standard antidepressants.