6. Lithium, Thyroid Hormones and Further Augmentation Strategies in Treatment-resistant Depression

  1. Siegfried Kasper MD2 and
  2. Stuart Montgomery MD3
  1. Robert Haußmann and
  2. Michael Bauer

Published Online: 5 FEB 2013

DOI: 10.1002/9781118556719.ch6

Treatment-resistant Depression

Treatment-resistant Depression

How to Cite

Kasper, S. and Montgomery, S. (2013) Lithium, Thyroid Hormones and Further Augmentation Strategies in Treatment-resistant Depression, in Treatment-resistant Depression, John Wiley & Sons, Oxford. doi: 10.1002/9781118556719.ch6

Author Information

  1. 2

    Professor and Chair, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna Austria

  2. 3

    Emeritus Professor of Psychiatry Professor of Psychiatry (retired), Imperial College of Science, Technology and Medicine, University of London, London UK

Author Information

  1. Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

Publication History

  1. Published Online: 5 FEB 2013
  2. Published Print: 8 APR 2013

ISBN Information

Print ISBN: 9781119952909

Online ISBN: 9781118556719

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Keywords:

  • depression;
  • treatment-resistance;
  • augmentation;
  • antidepressants;
  • lithium;
  • thyroid hormones

Summary

A variety of pharmacologically different nonantidepressant agents have been studied for their ability to augment the efficacy of antidepressants in depressed patients who do not respond sufficiently. Among the strategies reviewed in this chapter, augmentation with lithium is the best-evidenced, showing clear efficacy in a metaanalysis of 10 placebo-controlled trials. All other commonly used augmentation strategies described in this chapter are not well supported by sufficient data from randomised controlled trials (RCTs). There is also a lack of controlled comparator studies with different augmentation agents. Such studies are needed to better guide physicians in the treatment of nonresponders to standard antidepressants.