2. Nanofiber Technology for Controlling Stem Cell Functions and Tissue Engineering

  1. Murugan Ramalingam,
  2. Esmaiel Jabbari,
  3. Seeram Ramakrishna and
  4. Ali Khademhosseini
  1. Shayanti Mukherjee1,2,
  2. Jayarama Reddy Venugopal2,
  3. Rajeswari Ravichandran2,3,
  4. Murugan Ramalingam4,5,6,
  5. Michael Raghunath1,7 and
  6. Seeram Ramakrishna2,3,8

Published Online: 23 MAY 2013

DOI: 10.1002/9781118574775.ch2

Micro and Nanotechnologies in Engineering Stem Cells and Tissues

Micro and Nanotechnologies in Engineering Stem Cells and Tissues

How to Cite

Mukherjee, S., Venugopal, J. R., Ravichandran, R., Ramalingam, M., Raghunath, M. and Ramakrishna, S. (2013) Nanofiber Technology for Controlling Stem Cell Functions and Tissue Engineering, in Micro and Nanotechnologies in Engineering Stem Cells and Tissues (eds M. Ramalingam, E. Jabbari, S. Ramakrishna and A. Khademhosseini), John Wiley & Sons, Inc., Hoboken, New Jersey. doi: 10.1002/9781118574775.ch2

Author Information

  1. 1

    Division of Bioengineering, National University of Singapore, Singapore

  2. 2

    HEM Laboratory, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore

  3. 3

    Department of Mechanical Engineering, National University of Singapore, Singapore

  4. 4

    Centre for Stem Cell Research (CSCR), (A unit of Institute for Stem Cell Biology and Regenerative Medicine, Bengaluru) Christian Medical College Campus, Vellore, India

  5. 5

    Institut National de la Santé Et de la Recherche Médicale UMR977, Faculté de Chirurgie Dentaire, Université de Strasbourg, Strasbourg, France

  6. 6

    WPI-Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai, Japan

  7. 7

    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

  8. 8

    Institute of Materials Research and Engineering, a-star, Singapore

Publication History

  1. Published Online: 23 MAY 2013
  2. Published Print: 3 JUN 2013

ISBN Information

Print ISBN: 9781118140420

Online ISBN: 9781118574775

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Keywords:

  • electrospinning;
  • nanofiber technology;
  • nanofiber-based scaffolds;
  • regenerative medicine;
  • stem cell functions;
  • tissue engineering (TE)

Summary

Nanotechnology is an upcoming yet promising technology with respect to the development of well-established products. Nanofibers are potentially recent additions to materials in relation to tissue engineering (TE). Nanofiber-based scaffolds are being explored as scaffolds for TE applications. Electrospinning has developed into a versatile technique to fabricate polymeric nanofiber matrices, and the ability to incorporate bioactive therapeutic molecules without adversely affecting their structural integrity and biological activity using the mild electrospinning process has generated significant interest in polymeric nanofiber-based drug release patterns by changing the mode of encapsulation as well as by varying the matrix polymer. Scaffold composition and fabrication can be controlled to confirm desired properties and biofunctionalities. Interaction between the stem cells and nanofibers are crucial in a cell-scaffold matrix while using them for different TE applications. This chapter finally talks about the stem cell-nanofiber interactions in regenerative medicine and TE.