8. Paraneoplastic, Inherited Cancer Syndrome, and Environmental Carcinogen-Related Dermatoses

  1. Mario E. Lacouture MD
  1. Cindy England Owen and
  2. Jeffrey P. Callen

Published Online: 30 NOV 2013

DOI: 10.1002/9781118590638.ch8

Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients

Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients

How to Cite

Owen, C. E. and Callen, J. P. (2013) Paraneoplastic, Inherited Cancer Syndrome, and Environmental Carcinogen-Related Dermatoses, in Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients (ed M. E. Lacouture), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118590638.ch8

Editor Information

  1. Associate Member, Dermatology Service, Memorial Sloan-Kettering Cancer Center, Associate Professor, Department of Dermatology, Cornell University, New York, NY, USA

Author Information

  1. University of Louisville School of Medicine, Louisville, KY, USA

Publication History

  1. Published Online: 30 NOV 2013
  2. Published Print: 10 DEC 2013

ISBN Information

Print ISBN: 9780470621882

Online ISBN: 9781118590638

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Keywords:

  • Birt-Hogg-Dube (BHD);
  • ectopic acth-producing tumors;
  • environmental carcinogen-related dermatoses;
  • glucagonoma syndrome;
  • hormone-secreting tumors;
  • inflammatory paraneoplastic dermatoses;
  • inherited cancer syndrome;
  • paraneoplastic disorders;
  • Peutz-Jeghers syndrome (PJS);
  • skin changes

Summary

Skin findings can serve both as a marker of internal malignancy and for inherited syndromes that carry an increased cancer risk. Paraneoplastic dermatoses include a wide spectrum of inflammatory, proliferative, metabolic, and neoplastic disorders that do not directly involve tumor cells from the malignancy. Muir-Torre syndrome (MTS) is an autosomal dominant syndrome of associated sebaceous neoplasms, keratoacanthomas, and internal malignancy. Gardner syndrome is an autosomal dominant disorder characterized by extensive polyposis of the gastrointestinal tract, bony tumors, and cutaneous lesions. Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder that presents with pigmented mucosal lesions and hamartomotous polyps in the gastrointestinal tract. Birt-Hogg-Dube (BHD) is an autosomal dominant condition that presents with benign hair follicle tumors, and skin tags of the head and neck. Howel-Evans syndrome is an autosomal dominant condition characterized by the presence of thickened skin of the palms and soles (tylosis) and esophageal cancer.