11. Viral-Mediated Delivery of shRNA and miRNA

  1. Kun Cheng2 and
  2. Ram I. Mahato3
  1. Fredric P. Manfredsson

Published Online: 26 APR 2013

DOI: 10.1002/9781118610749.ch11

Advanced Delivery and Therapeutic Applications of RNAi

Advanced Delivery and Therapeutic Applications of RNAi

How to Cite

Manfredsson, F. P. (2013) Viral-Mediated Delivery of shRNA and miRNA, in Advanced Delivery and Therapeutic Applications of RNAi (eds K. Cheng and R. I. Mahato), John Wiley and Sons, Ltd, Chichester, UK. doi: 10.1002/9781118610749.ch11

Editor Information

  1. 2

    School of Pharmacy, University of Missouri-Kansas City, USA

  2. 3

    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, USA

Author Information

  1. Department of Translational Science and Molecular Medicine, Michigan State University, USA

Publication History

  1. Published Online: 26 APR 2013
  2. Published Print: 10 JUN 2013

ISBN Information

Print ISBN: 9781119976868

Online ISBN: 9781118610749

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Keywords:

  • short hairpin RNA;
  • RNA interference;
  • viral vector;
  • gene therapy;
  • gene expression

Summary

RNA interference (RNAi) has become increasingly used in biological research. In order to achieve the full benefit of RNA knockdown in vivo, continuous RNAi is now being induced by the use of viral vector-mediated production of short hairpin RNAs. This chapter will discuss various recombinant vectors and expression systems in use today to deliver these small molecules.