2. Analysis of siRNA Delivery Using Various Methodologies

  1. Kun Cheng2 and
  2. Ram I. Mahato3
  1. Yi Pei

Published Online: 26 APR 2013

DOI: 10.1002/9781118610749.ch2

Advanced Delivery and Therapeutic Applications of RNAi

Advanced Delivery and Therapeutic Applications of RNAi

How to Cite

Pei, Y. (2013) Analysis of siRNA Delivery Using Various Methodologies, in Advanced Delivery and Therapeutic Applications of RNAi (eds K. Cheng and R. I. Mahato), John Wiley and Sons, Ltd, Chichester, UK. doi: 10.1002/9781118610749.ch2

Editor Information

  1. 2

    School of Pharmacy, University of Missouri-Kansas City, USA

  2. 3

    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, USA

Author Information

  1. Department of RNA Therapeutics Merck Research Laboratories, USA

Publication History

  1. Published Online: 26 APR 2013
  2. Published Print: 10 JUN 2013

ISBN Information

Print ISBN: 9781119976868

Online ISBN: 9781118610749

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Keywords:

  • siRNA;
  • RISC;
  • in vivo delivery;
  • analytical methods

Summary

Several checkpoints for assessing siRNA delivery are discussed, together with an overview of various methods developed for analyzing delivered siRNA. In addition, selected reports from the literature are used as examples to demonstrate how analytical methods are integrated to analyze siRNA delivery.