7. Multifunctional RNAi Delivery Systems

  1. Kun Cheng2 and
  2. Ram I. Mahato3
  1. China Malakondaiah Kummitha,
  2. Anthony S. Malamas and
  3. Zheng-Rong Lu

Published Online: 26 APR 2013

DOI: 10.1002/9781118610749.ch7

Advanced Delivery and Therapeutic Applications of RNAi

Advanced Delivery and Therapeutic Applications of RNAi

How to Cite

Kummitha, C. M., Malamas, A. S. and Lu, Z.-R. (2013) Multifunctional RNAi Delivery Systems, in Advanced Delivery and Therapeutic Applications of RNAi (eds K. Cheng and R. I. Mahato), John Wiley and Sons, Ltd, Chichester, UK. doi: 10.1002/9781118610749.ch7

Editor Information

  1. 2

    School of Pharmacy, University of Missouri-Kansas City, USA

  2. 3

    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, USA

Author Information

  1. Biomedical Engineering, Case Western Reserve University, USA

Publication History

  1. Published Online: 26 APR 2013
  2. Published Print: 10 JUN 2013

ISBN Information

Print ISBN: 9781119976868

Online ISBN: 9781118610749



  • multifunctional siRNA delivery systems;
  • cationic lipids;
  • cationic polymers;
  • siRNA;
  • RNA interference


RNA interference (RNAi) is a promising therapeutic modality for silencing expression of disease-causing genes. Sequence-specific double-stranded small-interfering RNAs (siRNA) are the critical mediators of the RNAi process. Several siRNA candidates have been identified for the treatment of previously incurable diseases. However, the major hurdle in the clinical application of RNAi for treating a repertoire of diseases is the systemic delivery of therapeutic siRNAs into target cells with high efficiency. Efficient delivery methods are required for systemic siRNA delivery for the fullest application of RNAi in the clinic. This chapter describes a variety of lipid- and polymer-based multifunctional siRNA delivery systems designed for effective siRNA systemic delivery.