9. Development of Pharmaceutically Adapted Mesoporous Silica Nanoparticles for siRNA Delivery

  1. Kun Cheng2 and
  2. Ram I. Mahato3
  1. Wilson X. Mai,
  2. Tian Xia and
  3. Huan Meng

Published Online: 26 APR 2013

DOI: 10.1002/9781118610749.ch9

Advanced Delivery and Therapeutic Applications of RNAi

Advanced Delivery and Therapeutic Applications of RNAi

How to Cite

Mai, W. X., Xia, T. and Meng, H. (2013) Development of Pharmaceutically Adapted Mesoporous Silica Nanoparticles for siRNA Delivery, in Advanced Delivery and Therapeutic Applications of RNAi (eds K. Cheng and R. I. Mahato), John Wiley and Sons, Ltd, Chichester, UK. doi: 10.1002/9781118610749.ch9

Editor Information

  1. 2

    School of Pharmacy, University of Missouri-Kansas City, USA

  2. 3

    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, USA

Author Information

  1. Division of NanoMedicine, Department of Medicine, University of California, USA

Publication History

  1. Published Online: 26 APR 2013
  2. Published Print: 10 JUN 2013

ISBN Information

Print ISBN: 9781119976868

Online ISBN: 9781118610749

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Keywords:

  • mesoporous silica nanoparticle (MSNP);
  • inorganic nanocarrier;
  • surface modification;
  • siRNA delivery

Summary

Mesoporous silica nanoparticle (MSNP) is a multifunctional inorganic nanomaterial platform that offers a novel approach for siRNA delivery. It combines the robustness of the inorganic system with the ability of imaging, on-demand cargo release, and targeting. This chapter discusses the synthesis, surface modification, and applications of MSNP for siRNA delivery.